Establishing a Clinically Relevant Radiation Therapy Method for Preclinical Medulloblastoma Research

Craniospinal irradiation (CSI) is a cornerstone of pediatric brain cancer therapy, yet detailed, reproducible protocols for accurate CSI delivery in preclinical mouse models remain scarce, hindering translational research and the development of radiosensitizing strategies. We aimed to establish a clinically relevant, easily replicable radiation therapy protocol for medulloblastoma mouse models, providing a robust platform for preclinical evaluation of novel therapeutic combinations.

Citation:
Buck J, Howlett M, Hii H, Whitehouse J, Abbas Z, Carline B, Kuchibhotla M, Byrne J, Lawler JR, D'Alonzo RA, Hau E, Gill S, Gottardo NG, Ebert MA, Endersby R. Establishing a Clinically Relevant Radiation Therapy Method for Preclinical Medulloblastoma Research. Adv Radiat Oncol. 2026;11(11).

Keywords:
Pediatric brain cancer; radiation therapy strategies; preclinical mouse models

Abstract:
Craniospinal irradiation (CSI) is a cornerstone of pediatric brain cancer therapy, yet detailed, reproducible protocols for accurate CSI delivery in preclinical mouse models remain scarce, hindering translational research and the development of radiosensitizing strategies. We aimed to establish a clinically relevant, easily replicable radiation therapy protocol for medulloblastoma mouse models, providing a robust platform for preclinical evaluation of novel therapeutic combinations.