Skip to content
The Kids Research Institute Australia logo

Long-term antipsychotic use and cardiometabolic adverse effects in adults with non-psychotic disorders: A systematic review

Off-label antipsychotic prescribing for non-psychotic disorders is increasing, often at low doses and over extended periods. While cardiometabolic adverse effects are documented among individuals treated with antipsychotics for psychotic disorders, the consequences of long-term off-label antipsychotic use are not well-known.

Citation:
Radha Krishnan RP, Dzidowska M, …….. Quintrell E, Chan CH, et al. Long-term antipsychotic use and cardiometabolic adverse effects in adults with non-psychotic disorders: A systematic review. Psychiatry Res. 2026;364.

Keywords:
Antipsychotic; Cardiovascular and metabolic adverse effects; Non-psychotic conditions; Off-label disorders; Safety outcomes

Abstract:
Off-label antipsychotic prescribing for non-psychotic disorders is increasing, often at low doses and over extended periods. While cardiometabolic adverse effects are documented among individuals treated with antipsychotics for psychotic disorders, the consequences of long-term off-label antipsychotic use are not well-known.