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Prevention - what is the most promising approach?This paper is an editorial comment by Professor Patrick Holt on the potential for developing early intervention strategies in children with allergies and asthma
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Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhoodThe impact of breast milk feeding on susceptibility to asthma in childhood is highly controversial, due in part to failure of the majority of studies in the...
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Maternal Vitamin D Levels and the Autism Phenotype Among OffspringWe tested whether maternal vitamin D insufficiency during pregnancy is related to the autism phenotype.
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Sensitizing and Th2 Adjuvant Activity of Cysteine Protease AllergensHere, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa.
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Early aberrant antibody responses of aeroallergen sensitised people to subclinical bacterial infectionEarly aberrant antibody responses, aeroallergen sensitised people, subclinical bacterial infection
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Vitamin D and atopy and asthma phenotypes in childrenThe purpose of this Review was to give an overview of the recent research into whether a lack of vitamin D contributes to the development of atopy and asthma...
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Th2-polarisation of cellular immune memory to neonatal pertussis vaccinationCurrent infant vaccination against pertussis in North America and Australia requires three doses of vaccines including diphtheria, tetanus and acellular...
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Lung homing T-cell generation is dependent on strength and timing of antigen delivery to lymph nodesInhaled allergens are known for their immediate and ongoing effects in the respiratory tract (RT).
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Ontogeny of toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infantsStudies addressing the ontogeny of the innate immune system in early life have reported mainly on Toll-like receptor (TLR) responses in infants living in...
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Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheezeThe aim of this study was to explore associations between severe respiratory infections and atopy in early childhood with persisting wheeze and asthma.