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Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine ResponseEpidemiological studies have demonstrated that survivors of acute burn trauma are at long-term increased risk of developing a range of morbidities. The mechanisms underlying this increased risk remain unknown. This study aimed to determine whether burn injury leads to sustained immune dysfunction that may underpin long-term morbidity. Plasma and peripheral blood mononuclear cells were collected from 36 pediatric burn survivors >3 years after a non-severe burn injury (<10% total body surface area) and from age/sex-matched non-injured controls.
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Measuring early childhood development with The Early Human Capability Index (eHCI): a reliability and validity study in ChinaWith the importance of early childhood development more recognized by the international society, low-cost and cross-culturally comparable measures of early childhood development is in great demand, both in China and worldwide. In this study, we aim to test the psychometrics of the Chinese version of The Early Human Capability Index (eHCI), which is designed as a measurement for school readiness in large population.
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Global consensus on nutritional rickets: Implications for AustraliaWe conclude that updated global recommendations for therapy of nutritional rickets complement previously published position statements for Australia and New Zealand
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Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?Baseline signatures might contribute to identifying interventional targets to be modulated prior to vaccination in order to improve vaccination responses
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Epithelial Mesenchymal Transition in Respiratory Disease: Fact or FictionIn this translational review, the mechanisms, roles, and impact of epithelial-mesenchymal transition in chronic lung diseases are discussed
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Whole blood transcriptional responses of very preterm infants during late-onset sepsisBlood responses in very preterm infants with LOS are characterised by altered host immune responses that appear to reflect unbalanced immuno-metabolic homeostasis
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Airway Epithelial Cell Immunity Is Delayed During Rhinovirus Infection in Asthma and COPDWe propose that propensity for viral exacerbations of asthma and COPD relate to delayed expression of epithelial cell innate anti-viral immune genes
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Lessons from schools with high levels of support for students with type 1 diabetes: A qualitative studyThis project aimed to investigate how schools provide support for the psychosocial wellbeing and disease management of students with type 1 diabetes
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Development of a referral pathway framework for foetal alcohol spectrum disorder in the PilbaraThe process of referral pathway development provided a service mapping and gapping exercise to facilitate service integration
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Clinical protocol for a longitudinal cohort study to identify markers of vaccine immunogenicity in newborn infants in the gambia and papua New GuineaImmunity is distinct in early life and greater precision is required in our understanding of mechanisms of early life protection to inform development of new pediatric vaccines