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Research
Investigating Parental Observations of Early Autism Development in Simplex and Multiplex FamiliesPast research has highlighted the importance of early identification of developmental differences to improve targeted access to early interventions or supports. As such, it is of particular importance in the context of children at elevated likelihood of autism (such as where an older sibling has a diagnosis of autism), to better understand when and which early concerns are important as predictors of which children will benefit from pre-diagnostic supports.
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Child and Family Characteristics Associated with Symptoms of Anxiety in Autistic Children: A Biobank StudyAutistic children have an increased likelihood of anxiety, but more research is needed on the characteristics that predict various types of anxiety in this population.
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Parsing the heterogeneity of social motivation in autismSocial motivation is posited as a key factor in the expression of the autism phenotype. However, lack of precision in both conceptualization and measurement has impeded a thorough understanding of its diverse presentation and associated outcomes. This study addresses this gap by identifying subgroups of autism characterized by deficits in distinct facets of social motivation, relative to normative benchmarks.
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Subgroups of Temperament Associated with Social-Emotional Difficulties in Infants with Early Signs of AutismLinks between temperament and social-emotional difficulties are well-established in normative child development but remain poorly characterized in autism. We sought to characterize distinct temperament subgroups and their associations with concurrent internalizing and externalizing symptoms in a sample of 103 infants showing early signs of autism.
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Early motor function of children with autism spectrum disorder: A systematic reviewEarly motor impairments have been reported in children with neurodevelopmental disorders (NDD), but it is not clear if early detection of motor impairments can identify children at risk for NDD or how early such impairments might be detected. Our aim was to characterize early motor function in children later diagnosed with NDD relative to typically developing children or normative data.
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A broad autism phenotype expressed in facial morphologyThese data provide the first evidence for a broad autism phenotype expressed in a physical characteristic
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An integrative analysis of non-coding regulatory DNA variations associated with autism spectrum disorderOverall, we found that the regulatory variants in autism spectrum disorder cases were enriched in ASD-risk genes and genes involved in fetal neurodevelopment
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Increased facial asymmetry in autism spectrum conditions is associated with symptom presentationSignificantly greater depth-wise facial asymmetry was identified in autistic children relative to the two comparison groups
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Association of Genetic and Environmental Factors with Autism in a 5-Country CohortBased on population data from 5 countries, the heritability of ASD was estimated to be approximately 80%
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Evidence of a reduction over time in the behavioral severity of autistic disorder diagnosesWe examined whether there were changes over time in the qualitative and quantitative phenotype of individuals who received the diagnosis of Autistic Disorder.