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Research

Examining relationships between vitamin D over the first decade of life and development of asthma and allergy

This study shows for the first time the importance of considering vitamin D levels over a prolonged period during childhood, rather than at just one or two ages

Research

Developmental-associated dysregulation of innate anti-microbial immunity in early life as a determinant of susceptibility to atopic asthma

One of the strongest risk factors for asthma is having chest infections during infancy that are so severe that they trigger symptoms of fever & wheeze

News & Events

NHMRC funding awarded to support child health research

The Kids Research Institute Australia researchers have been awarded more than $10 million in research funding from the National Health and Medical Research Council (NHMRC).

News & Events

Switch on the immune system early

Findings by Professor Pat Holt revealed researchers had been heading down the wrong path in their battle strategy against respiratory allergy and asthma.

News & Events

Overseas trip will help unlock the asthma puzzle

One in ten Australians have asthma and Dr Kimberley Wang from The Kids Research Institute Australia is on a mission to find out what causes it.

News & Events

Volunteers needed for world-first trial to prevent asthma

Australian scientists have today launched a world first research trial into a treatment that could prevent asthma in high risk children.

Children's Lung Health

The Children's Lung Health Team investigates lung growth and development through infancy, childhood, adolescence and early adulthood, in health and in chronic lung disease, and the impact of preterm birth on lung health outcomes.

Research

Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways

nfants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunizations. They are also more likely to develop chronic respiratory diseases in later childhood. This study investigated the feasibility of epigenetic profiling to reveal endotype-specific molecular pathways with potential for early identification and immuno-modulation.

Research

Global change, climate change, and asthma in children: Direct and indirect effects - A WAO Pediatric Asthma Committee Report

The twenty-first century has seen a fundamental shift in disease epidemiology with anthropogenic environmental change emerging as the likely dominant factor affecting the distribution and severity of current and future human disease. This is especially true of allergic diseases and asthma with their intimate relationship with the natural environment.

Research

Impaired interferon response in plasmacytoid dendritic cells from children with persistent wheeze

Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.