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Research

Investigations into the role of ST2 in acute asthma in children

This study investigated the potential role of ST2 in children with acute asthma.

Research

Birthweight and the risk of childhood-onset type 1 diabetes

We investigated whether children who are heavier at birth have an increased risk of type 1 diabetes

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Hypoglycemia alarm enhancement using data fusion

The acceptance of closed-loop blood glucose (BG) control using continuous glucose monitoring systems (CGMS) is likely to improve.

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Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy

Topical application of tumors with the TLR7 agonist imiquimod is an effective adjunct treatment for a range of primary dermatological cancers.

Research

Airway narrowing assessed by anatomical optical coherence tomography in vitro: dynamic airway wall morphology and function

Previous histological and imaging studies have shown the presence of variability in the degree of bronchoconstriction of airways sampled at different locations.

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Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells

Tumor cell death potentially engages with the immune system. However, the efficacy of anti-tumor chemotherapy may be limited by tumor-driven...

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Effects of simulated tidal and deep breathing on immature airway contraction to acetylcholine and nerve stimulation

In adults, respiratory movements, such as tidal and deep breaths, reduce airway smooth muscle force and cause bronchodilation.

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Adult psychosocial outcomes of children with specific language impairment, pragmatic language impairment and autism

Evidence that some children also develop autistic symptomatology over time has raised suggestions that developmental language disorder...

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The common BDNF polymorphism may be a modifier of disease severity in Rett syndrome

Rett syndrome (RTT) is caused by mutations in the transcriptional repressor methyl CpG-binding protein 2 (MECP2).

Research

Siblings of children with disabilities: challenges and opportunities

Siblings of children with disabilities: challenges and opportunities