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Physician training programs significantly improve diagnosis in cases coded as anaphylaxis over time: A major factor compounding time-trend data?We conducted an investigation of all cases coded as anaphylaxis presenting to the main tertiary PED in Perth, Australia, where all coding is performed by staff.
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The Microbiome and Mental Health: Looking Back, Moving Forward with Lessons from Allergic DiseasesThe microbiome is intimately connected to diet, nutrition, and other lifestyle variables
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Immune-Microbiota Interactions: Dysbiosis as a Global Health IssueThe implications of the microbiome extend to virtually every branch of medicine, biopsychosocial and environmental sciences
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Food for thought: progress in understanding the causes and mechanisms of food allergyTreatments for food allergy are still lacking, yet progress is being made, and immunotherapy appears more effective than dietary avoidance.
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A Family's Journey at JHC: Analyses of routinely collected dataDesiree Silva MBBS, FRACP, MPH, PhD Co-Director, ORIGINS desiree.silva@thekids.org.au Co-Head, The ORIGINS Project Professor Desiree Silva is
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ADAPTS: Antibiotic Dysbiosis And Probiotics Trial in infantSDesiree Peter Silva Richmond MBBS, FRACP, MPH, PhD MBBS MRCP(UK) FRACP Co-Director, ORIGINS Head, Vaccine Trials Group desiree.silva@thekids.org.au
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Environmental and lifestyle changes in the antenatal population over the past three decades: A comparative study utilising Raine Study and Joondalup Health Campus birth cohort dataInvestigators: Catherine Nguyen, Lauren Fisher, Lauren Nguyen This study investigated changes in prevalence of environmental and lifestyle risk
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ORIGINS community wellbeing during the COVID-19 pandemicDesiree Dr Jackie Lisa Susan Silva Davis Gibson Prescott MBBS, FRACP, MPH, PhD BSc (Hons), PGradDipHlthProm, PhD BA (Hons), MPsych, PhD MBBS BMedSci
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The Flourishing Child: Understanding how Adults and Children Perceive Flourishing from the Start of LifeThe current narrative surrounding children’s health and wellbeing often focuses on adversity and dysregulation with a lack of positive messaging. However, promoting protective and buffering factors may be as important as reducing adverse exposures. While the concept of flourishing is commonly applied in the context of adults, defining what flourishing means for children in current academic literature remains unclear.
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Probiotic peanut oral immunotherapy versus oral immunotherapy and placebo in children with peanut allergy in Australia (PPOIT-003): a multicentre, randomised, phase 2b trialOral immunotherapy is effective at inducing desensitisation to allergens and induces sustained unresponsiveness (ie, clinical remission) in a subset of patients, but causes frequent reactions. We aimed to investigate whether addition of a probiotic adjuvant improved the efficacy or safety of peanut oral immunotherapy.