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A microRNA-based dynamic risk score for type 1 diabetesIdentifying individuals at high risk of type 1 diabetes (T1D) is crucial as disease-delaying medications are available. Here we report a microRNA (miRNA)-based dynamic (responsive to the environment) risk score developed using multicenter, multiethnic and multicountry ('multicontext') cohorts for T1D risk stratification. Discovery (wet and dry lab) analysis identified 50 miRNAs associated with functional β cell loss, which is a hallmark of T1D.
Research
Study Protocol for a Stepped-Wedge Cluster (Nested) Randomized Controlled Trial of Antenatal Colostrum Expression (ACE) Instruction in First-Time Mothers: The ACE StudyAlthough many mothers initiate breastfeeding, supplementation with human-milk substitutes (formula) during the birth hospitalization is common and has been associated with early breastfeeding cessation. Colostrum hand expressed in the last few weeks before birth, known as antenatal colostrum expression (ACE), can be used instead of human-milk substitutes. However, evidence is lacking on the efficacy of ACE on breastfeeding outcomes and in non-diabetic mothers.
Research
Protocol for the Australian Type 1 Diabetes National Screening Pilot: Assessing the feasibility and acceptability of three general population screening models in childrenOne third of Australian children diagnosed with type 1 diabetes present with life-threatening diabetic ketoacidosis (DKA) at diagnosis. Screening for early-stage, presymptomatic type 1 diabetes, with ongoing follow-up, can substantially reduce this risk (<5% risk). Several screening models are being trialled internationally, without consensus on the optimal approach. This pilot study aims to assess three models for a routine, population-wide screening programme in Australia.
News & Events
High hopes for preventing lowsResearchers led by the team at the Children’s Diabetes Centre at The Kids have taken a key step to a fully automated closed-loop insulin delivery system.
News & Events
30% of children at risk of future heart diseaseAlmost 30% of 14-year-old Australian children fall within a group identified as being at future increased risk of heart disease, type 2 diabetes or stroke
Research
The effect of short-term use of the Guardian RT continuous glucose monitoring system on fear of hypoglycaemia in patients with type 1 diabetes mellitusThis study examines whether the short-term use of a continuous glucose monitor can reduce the fear of hypoglycaemia in individuals with type 1 diabetes...
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Type 2 Diabetes in Indigenous Australian childrenRates of type 2 diabetes are higher among Indigenous than non-Indigenous Australian children and adolescents.
Research
Type 1 and Type 2 Diabetes DNA bankA register which stores demographic and clinical data on all patients attending the diabetes clinic at Princess Margaret Hospital
Research
Sprint proof of concept studyThis study will evaluate the effect of two types of aerobic exercise
Research
Minimizing Hypoglycemia in DiabetesHypoglycemia caused by treatment with a sulfonylurea, a glinide, or insulin coupled with compromised defenses against the resulting falling plasma glucose...