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PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding proteinOur findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis
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Exposure to chorioamnionitis alters the monocyte transcriptional response to the neonatal pathogen Staphylococcus epidermidisOur findings suggest that prenatal exposure to inflammation may alter the risk of sepsis in preterm infants partly by modulation of monocyte responses to pathogens
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Tryptophan and arginine catabolic enzymes and regulatory cytokines in clinically isolated syndrome and multiple sclerosisHigher IDO and ARG expression in clinically isolated syndrome and multiple sclerosis provides one sustained homeostatic mechanism to control multiple sclerosis-associated inflammation
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Structure-function relationships of the neisserial EptA enzyme responsible for phosphoethanolamine decoration of lipid A: Rationale for drug targetingThis review concentrates on the phosphoethanolamine decoration of lipid A in the pathogenic species of the genus Neisseria
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Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthoodLung airflow measurements track from birth into early adulthood, suggesting a permanent and stable airway framework is laid down in the antenatal period
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Reducing harms related to alcohol use in pregnancy – policy and practice recommendationsThis issues brief outlines opportunities for change to support reduction of harms related to alcohol use in pregnancy
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Infant removals: The need to address the over-representation of Aboriginal infants and community concerns of another ‘stolen generation’The disparity between Aboriginal and non-Aboriginal infant removals needs to be seen as a priority requiring urgent action to prevent further intergenerational trauma
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Understanding group A streptococcal pharyngitis and skin infections as causes of rheumatic fever: Protocol for a prospective disease incidence studyThis study will identify the incidence of true Group A Streptococcal pharyngitis and serological responses to Group A Streptococcal GAS skin infections
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The Great Recession and Children’s Mental Health in AustraliaThis paper analyzes the effects of “shocks” to community-level unemployment expectations, induced by the Great Recession, on children’s mental well-being
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Atypical nested 22q11.2 duplications are associated with neurodevelopmental phenotypes including autism spectrum disorder with incomplete penetranceOur findings contribute to the genotype–phenotype data for atypical nested 22q11.2 duplications, with implications for genetic counseling