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Research

Incidental inequity

Reporting incidental genomic findings requires various considerations. One of these is that 'the clinical validity and utility of variants should be known'.

Research

The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo

Our findings demonstrate that Ultra-High-Risk groups evidence a similar clinical risk profile when we expand this beyond transition to psychosis

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Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma

This study demonstrates novel intrinsic differences in tight junctions gene and protein expression between airway epithelial cells of children with and without asthma

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Effectiveness of a 3 + 0 pneumococcal conjugate vaccine schedule against invasive pneumococcal disease among a birth cohort of 1.4 million children in Australia

Our population-based cohort study demonstrates that >90% coverage in the first year of a universal 3 + 0 PCV program provided high population-level protection

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Burden of cardiovascular diseases in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study

The age-standardized disability-adjusted life years rates in the Eastern Mediterranean Region are considerably higher than the global average

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Vitamin D is crucial for maternal care and offspring social behaviour in rats

These data highlight that early life levels of vitamin D are an important consideration for maternal behavioural adaptations as well as offspring neuropsychiatry

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The influence of incomplete case ascertainment on measures of vaccine efficacy

A biologically active vaccine may produce a low measured vaccine efficacy under a range of epidemiological, vaccine-related and logistical conditions

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A profile of social, separation and generalized anxiety disorders in an Australian nationally representative sample of children and adolescents

Social, separation and generalized anxiety disorders in young people are relatively common and impairing, with a high level of comorbidity

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The glycaemic benefits of a very-low-carbohydrate ketogenic diet in adults with Type 1 diabetes mellitus may be opposed by increased hypoglycaemia risk and dyslipidaemia

This study provides the first evidence that, ketogenic diets in adults with Type 1 diabetes are associated with excellent HbA1c levels and little glycaemic variability

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Immunological processes driving IgE sensitisation and disease development in males and females

In this review, we discuss recent mechanistic studies casting further light on how the expression of sex hormones may influence the innate and adaptive immune system