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Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factorsEpigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs associated with body mass index, 10 with waist circumference and 9 with subcutaneous fat thickness.
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Type 1 DiabetesA lifelong auto-immune condition that can affect anyone, but is most commonly diagnosed in childhood.
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Investigating associations between birth order and autism diagnostic phenotypesBirth order effects have been linked to variability in intelligence, educational attainment and sexual orientation. First- and later-born children have been linked to an increased likelihood of an Autism Spectrum Disorder (ASD) diagnosis, with a smaller body of evidence implicating decreases in cognitive functioning with increased birth order.
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Anaphylaxis triggered by benzyl benzoate in a preparation of depot testosterone undecanoateWe report the first case of an anaphylactic reaction to Reandron 1000 (depot testosterone undecanoate with a castor oil and benzyl benzoate vehicle).
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Neurocognitive Outcomes in Young Adults With Early-Onset Type 1 DiabetesThe aim of this study was to reexamine the neurocognitive function of a cohort of young adults with early-onset type 1 diabetes and compare their cognitive...
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Lower cardiorespiratory fitness in children with Type 1 diabetesThe present study aimed to compare cardiorespiratory fitness levels in children with and without Type 1 diabetes.
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Perinatal risk factors for childhood Type 1 diabetes in Western Australia - a population-based study (1980-2002)To investigate perinatal risk factors for childhood Type 1 diabetes in Western Australia, using a complete population-based cohort.
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A Database of the Complications of Obesity in ChildrenThe Obesity Database records the characteristics and medical complications of children with obesity who present to treatment at Princess Margaret Hospital
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Oral Insulin TrialTo see if giving insulin by mouth (in a capsule) will delay or prevent T1DM in people at increased risk of developing diabetes.
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Feasibility of 24-hour hybrid closed loop insulin delivery in free living conditionsThe aim of this study is to see if the Medtronic hybrid closed loop system, a portable artificial pancreas is feasibly to use in the home.