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Variation over time in medical conditions and health service utilization of children with Down syndrome.

The contributors, all world experts in their fields, also discuss what we can learn from the presence of co-morbidities.

Overview of Health Issues in School-aged Children with Down Syndrome

Physical and mental health in mothers of children with Down syndrome.

Down syndrome, also known as Trisomy 21, is one of the most common chromosome abnormalities in humans. It occurs when a child's cells end up with 47 chromosomes instead of the usual 46. Down syndrome causes intellectual disability and other physical and learning challenges.

Tourette syndrome is a neurodevelopmental disorder characterised by uncontrollable movements and vocalisations known as tics.

The behavioral phenotype of neurogenetic disorders associated with intellectual disability often includes psychiatric comorbidity. The objectives of this systematic review and meta-analysis were to systematically review the prevalence of psychiatric disorders and symptoms in children and adolescents

Whilst gastrostomy insertion was associated with lower survival rates than children without gastrostomy, survival improved with time

Gastrostomy was associated with health benefits including reduced all-cause and epilepsy hospitalizations, but was not protective against acute LRTI

Gastrostomy is increasingly used in multiple neurological conditions associated with intellectual disability, with no apparent accessibility barriers