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Breastfeeding has been associated with multiple developmental advantages for the infant; however, there have also been a number of studies that find...
Improved nutrition is the major proven benefit of newborn screening programmes for cystic fibrosis (CF) and is associated with better clinical outcomes.
In healthy individuals, deep inspiration produces bronchodilation and reduced airway responsiveness, which may be a response of the airway wall to mechanical...
Rates and types of hospitalisations for children who have subsequent contact with the child protection system: a population based case-control study
We investigated whether children who are heavier at birth have an increased risk of type 1 diabetes
Evaluating Early Childhood Education and Care
The aims of the present study were to (i) examine the relationship between children's degree of adiposity and psychosocial functioning; and (ii) compare patterns of clustering of psychosocial measures between healthy weight and overweight/obese children.
Epigenomic research at The Kids explores the links between childhood disease and the molecular hallmarks of epigenetic control.
The Early Human Capability Index is a holistic measure intended to capture early child development across diverse cultures and contexts.
Characterized by early-onset seizures, global developmental delay and severe motor deficits, CDKL5 deficiency disorder is caused by pathogenic variants in the cyclin-dependent kinase-like 5 gene. Previous efforts to investigate genotype-phenotype relationships have been limited due to small numbers of recurrent mutations and small cohort sizes. Using data from the International CDKL5 Disorder Database we examined genotype-phenotype relationships for 13 recurrent CDKL5 variants and the previously analyzed historic variant groupings. We have applied the CDKL5 Developmental Score (CDS) and an adapted version of the CDKL5 Clinical Severity Assessment (CCSA), to grade the severity of phenotype and developmental outcomes for 285 individuals with CDKL5 variants.