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Research
Growth of the airway smooth muscle layer from late gestation to childhood is mediated initially by hypertrophy and subsequently hyperplasiaThe airway smooth muscle (ASM) layer thickens during development. Identifying the mechanism(s) for normal structural maturation of the ASM reveals pathways susceptible to disease processes. This study characterized thickening of the ASM layer from foetal life to childhood and elucidated the underlying mechanism in terms of hypertrophy, hyperplasia and extracellular matrix (ECM) deposition.
Research
Interpregnancy interval and the risk of oppositional defiant disorder in offspringThe study aimed to investigate the association between interpregnancy interval (IPI) and parent-reported oppositional defiant disorder (ODD) in offspring at 7 and 10 years of age. We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC), an ongoing population-based longitudinal study based in Bristol, United Kingdom (UK).
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Outcomes in extremely low birth weight (≤500 g) preterm infants: A Western Australian experienceExtremely preterm infant survival has significantly improved with advanced neonatal care; however outcomes of infants born with birth weight ≤500 g remain poor. We aimed to review outcomes of this cohort in our Institution.
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Reporting Both Unadjusted and Adjusted Estimates Is Essential to the Interpretation of Randomized Clinical Trial Results - ReplyAndrew Matt Videos Whitehouse Watch and listen to Andrew Cooper PhD BCA Marketing, BSc Statistics and Applied Statistics, PhD Deputy Director (
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Addressing Race in Pulmonary Function Testing by Aligning Intent and Evidence With Practice and PerceptionThe practice of using race or ethnicity in medicine to explain differences between individuals is being called into question because it may contribute to biased medical care and research that perpetuates health disparities and structural racism.
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Rheumatic Heart Disease in Pregnancy: New Strategies for an Old Disease?RHD in pregnancy (RHD-P) is associated with an increased burden of maternal and perinatal morbidity and mortality. A sequellae of rheumatic fever resulting in heart valve damage if untreated, RHD is twice as common in women. In providing an historical overview, this commentary provides context for prevention and treatment in the 21 st century. Four underlying themes inform much of the literature on RHD-P: its association with inequities; often-complex care requirements; demands for integrated care models, and a life-course approach.
News & Events
ORIGINS begins collecting baby teeth to unlock new insights into child health research.All participating families to receive $10 e-voucher for this generous donation.*
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International Women's Day 2025Hear from Avril Bezant, ORIGINS Data Coordinator, and Alexis Harun, ORIGINS Paediatric Coordinator, and be reminded that it’s never too late to pursue your passion along with their hopes for women entering a STEM career.
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ORIGINS Features at The CAHS SymposiumORIGINS featured heavily at this years Child and Adolescent Health Services (CAHS) Symposium, with presentations from our Co-Director, Professor Desiree Silva, and ORIGINS Data Manager, Dr Sarah Whalan.
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The Power of Longitudinal Cohorts – The 2024 ORIGINS ShowcaseYesterday, we were delighted to host close to 200 people at The ORIGINS 2024 Showcase, which explored the power of longitudinal cohorts, now and in