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A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart diseaseFew children and adolescents receiving BPG as secondary prophylaxis will achieve concentrations >0.02 mg/L for the majority of the time between injections
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Treatment, prevention and public health management of impetigo, scabies, crusted scabies and fungal skin infections in endemic populations: a systematic reviewSystematic review of the treatment, prevention and public health control of skin infections in resource-limited settings where skin infections are endemic
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Infectious diseases clinician's variation in the management of pediatric Staphylococcus aureus bacteraemia and equipoise for clinical trialsLarge variation in antibiotic prescribing amongst clinicians is demonstrated and increased, corresponding with escalating case complexity and persisting MRSA bacteraemia
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Direct infant UV light exposure is associated with eczema and immune developmentThis study is the first to demonstrate an association between greater direct UV light exposures in early infancy with lower incidence of eczema
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Association between psychotic experiences and non-accidental self-injury: results from a nationally representative survey of adolescentsAdolescents reporting any sychotic experiences in the past 12 months reported increased likelihood of non-accidental self-injury in the same time period
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Key paediatric messages from the 2018 European Respiratory Society International CongressGroup Chairs and early career members highlight some of the most interesting findings in the field of paediatrics presented at the 2018 international ERS Congress
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Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosisThese findings indicate that early CF lung disease is characterized by an increased mucus burden and inflammatory markers without infection or structural lung disease
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Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweightWe find that DNA methylation in neonatal blood is associated with birthweight, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation
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Dendritic cells and cancer: From biology to therapeutic interventionIn this review, we discuss the different subsets of tumor-infiltrating dendritic cells and their role in anti-tumor immunity
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Statistical Analysis Plan for "An international study of isoelectric electroencephalography events in infants and young children during anesthesia for surgery"This Statistical Analysis Plan details the statistical procedures to be applied for the analysis of data for the multicenter electroencephalography study