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Risk factors for bronchial hyperresponsiveness in teenagers differ with sex and atopic statusSex-related differences in bronchial hyperresponsiveness (BHR) have been reported in adolescents, but the mechanisms remain obscure.
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Defective respiratory tract immune surveillance in asthma : A primary causal factor in disease onset and progressionThe relative importance of respiratory viral infections vs inhalant allergy in asthma pathogenesis is the subject of ongoing debate.
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Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitisAtopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic...
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Persistent Effects of Maternal Smoking during Pregnancy on Lung Function and Asthma in AdolescentsThe extent to which maternal smoking in pregnancy (MSP) has persisting effects on respiratory health remains uncertain and the mechanisms involved are not...
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Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of ageThis paper examines whether a Vitamin D deficiency during pregnancy affects the child's lung function predisposition towards lung disease such as asthma.
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Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) studyThis genome-wide association study (GWAS) utilises data from the Western Australian Pregnancy Cohort (Raine) Study for 25-hydroxyvitamin D (25(OH)D) levels...
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Whole-cell pertussis vaccine in early infancy for the prevention of allergyThis is a protocol for a Cochrane Review (intervention). The objectives were to assess the efficacy and safety of whole‐cell pertussis (wP) vaccinations in comparison to acellular pertussis (aP) vaccinations in early infancy for the prevention of atopic diseases in children.
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Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitisRecent birth cohort studies showed a significant interaction between cat ownership at birth and mutations in FLG on the development of early‐onset atopic dermatitis
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European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulationAtopic dermatitis is a common inflammatory skin condition and prior genome-wide association studies have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date combining previously reported cohorts with additional available data.