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Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheezeThe aim of this study was to explore associations between severe respiratory infections and atopy in early childhood with persisting wheeze and asthma.
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Changes in thymic regulatory T-cell maturation from birth to puberty: Differences in atopic childrenWe report vaccine efficacy against CIN3+ and adenocarcinoma in situ (AIS) in the end-of-study analysis of PATRICIA (PApilloma TRIal against Cancer In young...
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The role of chronic infection in children with otitis media with effusion: Evidence for intracellular persistence of bacteriaDemonstrate mucosal bacterial infection in children with otitis media with effusion (OME).
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A DTPa-HBV-IPV vaccine for primary vaccination of infantsCombined vaccines have an increasingly important role to play in delivering these antigens acceptably.
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Dahlem ConferenceThere is increasing evidence that the functional state of the immune system at birth is predictive of the kinetics of immune maturation in early infancy.
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A retrospective population-based cohort study identifying target areas for prevention of acute lower respiratory infections in childrenAcute lower respiratory infections (ALRI) are a major cause of hospitalisation in young children
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Polymorphisms in key innate immune genes and their effects on measles vaccine responses and vaccine failure in children from MozambiqueDespite an effective vaccine, measles remains a major health problem globally, particularly in developing countries. More than 30% of children show primary...
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Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthyNeisseria meningitidis serogroup B is a major cause of invasive meningococcal disease, but a broadly protective vaccine is not currently licensed. A bivalent...
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International Pediatric COVID-19 Severity over the Course of the PandemicMultiple SARS-CoV-2 variants have emerged over the COVID-19 pandemic. The implications for COVID-19 severity in children worldwide are unclear. The objective was to determine whether the dominant circulating SARS-CoV-2 variants of concern (VOCs) were associated with differences in COVID-19 severity among hospitalized children.
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Tracing the transmission of mpox through wastewater surveillance in Southeast AsiaHigh population density and tourism in Southeast Asia increase the risk of mpox due to frequent interpersonal contacts. Our wastewater surveillance in six Southeast Asian countries revealed positive signals for Monkeypox virus (MPXV) DNA, indicating local transmission. This alerts clinicians and helps allocate resources like testing, vaccines and therapeutics in resource-limited countries.