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In vitro liver models combined with metabolomics approaches offer promising alternatives to animal testing in toxicology. In this study, we investigated concentration-dependent effects of hydrogen peroxide on the intra- and extracellular metabolome of HepG2 cells using 1H Nuclear Magnetic Resonance spectroscopy.
University students face obstacles while pursuing their goals, and these challenges risk undermining their mental health. Goal flexibility has been identified as beneficial for promoting well-being and protecting mental health; however, the relationship between goal flexibility and mental health challenges remains underexplored.
There is a lack of digital gatekeeper resources developed for parents to assist them in recognising and responding to mental health problems in their children and adolescents. We aimed to address this by exploring parents' mental health information needs, and to iteratively develop and design a resource incorporating their feedback.
Online sports betting has become a profitable segment of the global gambling industry, with young men identified as the demographic most likely to engage in online sports betting and at risk of gambling problems.
Off-label antipsychotic prescribing for non-psychotic disorders is increasing, often at low doses and over extended periods. While cardiometabolic adverse effects are documented among individuals treated with antipsychotics for psychotic disorders, the consequences of long-term off-label antipsychotic use are not well-known.
Social anxiety, peer victimisation, and social support are key issues during mid-childhood that provide important influence in the later adolescent years. While extensive research has evaluated these constructs in isolation and during adolescence, almost no longitudinal studies have evaluated relationships between them during mid-childhood.
To characterize sleep profiles in individuals with neurogenetic disorders (NGDs) and examine the contribution of key clinical and psychiatric symptoms to these profiles.
Conversion practices (sometimes referred to as 'conversion therapy') refer to interventions that aim to change a person's sexual orientation or gender identity. While these are often associated with faith-based settings, they can also occur in secular healthcare contexts. The practices are associated with significant psychological harm.
This study quantifies the short-term risk profiles of seven severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2) vaccines-Comirnaty Bivalent BA.1, Comirnaty Bivalent BA.4-5, Comirnaty XBB.1.5, Spikevax Bivalent BA.1, Spikevax Bivalent BA.4-5, Spikevax XBB.1.5 and Nuvaxovid-administered as booster doses in Australia.
Ewing Sarcoma of the pelvis has poorer outcomes than other anatomical sites, with complex anatomy often precluding resection with wide margins. The role of postoperative radiotherapy (RT) in improving outcomes remains undefined. A systematic review using Medline, Embase and Cochrane databases (1972-April 2024) evaluated postoperative RT's impact on local recurrence, event-free survival and overall survival. Twenty-nine retrospective studies (21 to 296 patients) met inclusion criteria, with 28 rated good quality.