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The advent of recombinant allergens and allergen cloning Authors:When the allergen nomenclature system was adopted in 1986, allergens were identified by their behavior on electrophoresis and chromatography...
Research
Maternal and umbilical cord androgen concentrations do not predict digit ratio (2D:4D) in girls:Digit ratio (2D:4D) is widely used as a marker of prenatal androgen exposure
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Relationship between environmental exposures in children and adult lung disease: the case for outdoor exposuresThere is a growing understanding that chronic respiratory diseases in adults have their origins in early life
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Vector fields of risk: A new approach to the geographical representation of childhood asthmaOne of the major challenges in health studies with a spatial dimension is to produce valid and meaningful geographical representations of risk.
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Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjectsThe aims of this study were to investigate kinin receptor expression on eosinophils of asthmatic and healthy subjects
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The effects of maternal smoking on early mucosal immunity and sensitization at 12 months of ageIn this study, we examined the effects of maternal smoking as a major adverse exposure in early life, on mucosal immune function and allergen sensitization...
The Airway Epithelial Research Team is investigating the role of the epithelium in the development of airway diseases including asthma, cystic fibrosis and lung transplant rejection.
Research
Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infectionPoor maternal diet during pregnancy is a risk factor for severe lower respiratory infections in the offspring, but the underlying mechanisms remain elusive. Here, we demonstrate that in mice a maternal low-fiber diet led to enhanced LRI severity in infants because of delayed plasmacytoid dendritic cell recruitment and perturbation of regulatory T cell expansion in the lungs.
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Association between pertussis vaccination in infancy and childhood asthma: A population-based record linkage cohort studyAsthma is among the commonest noncommunicable diseases of childhood and often occurs with other atopic comorbidities. A previous case-control study found evidence that compared to children who received acellular pertussis (aP) vaccines in early infancy, children who received one or more doses of whole-cell pertussis (wP) vaccine had lower risk of developing IgE-mediated food allergy. We hypothesized that wP vaccination in early infancy might protect against atopic asthma in childhood.
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Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmaticsOur findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure