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Research
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagusBarrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia,...
Research
Statistical adjustment of genotyping error in a case-control study of childhood leukaemiaGenotyping has become more cost-effective and less invasive with the use of buccal cell...
Research
Identification of suitable endogenous control genes for microRNA expression profiling of childhood medulloblastoma and human neural stem cellsMedulloblastoma (MB) is the most common type of malignant childhood brain tumour.
Research
Genetic and functional evaluation of the role of DLL1 in susceptibility to visceral leishmaniasis in IndiaChromosome 6q26-27 is linked to susceptibility to visceral leishmaniasis (VL) in Brazil and Sudan.
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Improving Outcome Reporting in Paediatric Airway Management in Clinical Trials (IMPACT): A Study Protocol for Core Outcomes and Clinical EndpointsAlthough clinical trials are fundamental to advancing evidence-based practice, significant heterogeneity in outcome reporting poses a considerable challenge to the validity of systematic reviews. This inconsistency impedes the ability to compare, synthesise and interpret research findings effectively. In the field of paediatric airway management, this issue is particularly relevant because of the low incidence of critical events and the related high morbidity and mortality. The issue of inadequate and variable outcome reporting in clinical trials has been widely acknowledged, necessitating initiatives to enhance the quality of future research.
Research
“I don't really exist here”: A reflexive thematic analysis of dissociative symptoms described by adolescents and their parents and cliniciansDissociative symptoms are associated with a range of negative outcomes, yet little is understood about how adolescents experience dissociation in their daily lives. This study aimed to describe adolescents’ dissociative symptoms from the perspective of adolescents, their parents, and their treating clinicians.
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Characterizing Transdiagnostic Processes Underlying the Drive to Socially Engage: A Multimeasurement Factor Analytic InvestigationAltered drive to socially engage is a transdiagnostic feature across multiple psychopathologies. Yet, lack of clarity regarding specific processes that constitute social drive, along with insufficient measurement methods, has hindered understanding in this area. This study ascertained the feasibility of approximating difficulties within specific fine-grained social drive processes as proposed by 2 theoretical frameworks: “orienting,” “wanting,” “pursuing,” “liking,” “learning,” and “reticence” within a reward processing framework and “orienting,” “seeking and maintaining,” and “liking” within a social motivation framework.
Research
Indigenous infants in remote Australia retain an ancestral gut microbiome despite encroaching Westernization
Studies of traditional Indigenous compared to 'Western' gut microbiomes are underrepresented, and lacking in young children, limiting knowledge of early-life microbiomes in different cultural contexts. Here we analyze the gut metagenomes of 50 Indigenous Australian infants (median age
Research
Quantitative measures of subjective wellbeing for adolescents: a scoping review and synthesis of comparable dataEfforts to promote adolescent wellbeing are of increasing global interest. Although the ability to measure wellbeing is essential for identifying disparities between and within populations, and for tracking progress in improving wellbeing, the best way to measure this elusive concept in adolescents is unclear.
Research
Experiences and Recognition of Intimate Partner Violence among a Community-Sample of LGBTIQA + People in Western AustraliaLGBTIQA + people experience intimate partner violence (IPV) at higher rates than non-LGBTIQA + people but under-utilize professional support services, and the reasons for this are poorly understood. This study examined IPV experiences, recognition of IPV, service utilization, and support needs among a self-selected sample of 523 LGBTIQA + adults in Western Australia.