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Feto-placental vascular structure and in silico haemodynamics: Of mice, rats, and humanThe complex arborization of the feto-placental vasculature is crucial for optimal fetal nutrition, waste exchange and ultimately, development. Ethical and experimental limitations constrain research into the human placenta, hence experimental animal models such as mice and rats, are crucial to understand placental function. It is unclear how well the mouse and rat feto-placental vascular structure emulates human. Moreover, the implications of differences in vascular structure, especially in arborization, for placental function remain unclear.
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Treatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse modelTreatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model.
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Early-life exposure to electronic cigarettes: cause for concernThere are a multitude of ways that, with respect to early-life exposures and health, electronic nicotine delivery systems are a cause for concern
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The Evolving Landscape of e-Cigarettes: A Systematic Review of Recent EvidenceThis review focuses on smokers and nonsmokers and evaluates the most recent data regarding the potential health effects of e-cigarettes
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Geogenic PM10 exposure exacerbates responses to influenza infectionThis study aimed to determine whether chronic, low-dose exposure to geogenic particulate matter <10μm diameter (PM10) exacerbates viral infections of the...
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Chronic carbon dioxide exposure: an unrecognised health risk of climate change?Alexander Larcombe BScEnv (Hons) PhD Honorary Research Fellow Honorary Research Fellow Associate Professor Alexander Larcombe began work at The Kids
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Understanding how viral infection in early life impacts on lung function in adulthoodAlexander David Deborah Larcombe Martino Strickland BScEnv (Hons) PhD BSc PhD PhD Honorary Research Fellow Head, Chronic Diseases Research Head,
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In utero cigarette smoke exposure impairs somatic and lung growth in BALB/c miceThe aim of this study was to assess whether in utero tobacco smoke exposure alone affects early-life lung growth and development. Pregnant BALB/c mice...
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Sensitizing and Th2 Adjuvant Activity of Cysteine Protease AllergensHere, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa.
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Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infectionImmunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung...