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Comparative analysis of the full genome of Helicobacter pylori isolate sahul64 identifies genes of high divergenceGenome sequence of Sahul64, an H. pylori strain isolated from an indigenous Australian
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Genetic susceptibility to otitis media in childhoodReviewed in this article these studies have identified positive association at 21 genes with association at five of these replicated in independent populations.
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FBXO11, a regulator of the TGFΒ pathway, is associated with severe otitis media in Western Australian childrenOtitis media (OM) is a common childhood disease characterised by middle ear inflammation following infection
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Translating aboriginal genomics — four letters closing the gapEstablishing a genomic reference for Australian Aboriginal populations
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A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control StudiesThese results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data
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Common and Rare Genetic Variants That Could Contribute to Severe Otitis Media in an Australian Aboriginal PopulationOur goal was to identify genetic risk factors for severe otitis media (OM) in Aboriginal Australians.
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Zika Virus Changes Methylation of Genes Involved in Immune Response and Neural Development in Brazilian Babies Born With Congenital MicrocephalyThe recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation.
News & Events
Decades-old work picked up by Google’s DeepMind leads to global scientific breakthroughA researcher's work from 20 years ago has helped to crack one of biology’s biggest mysteries.
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Host and parasite genomics, an Australasian perspectiveThe last decade has seen rapid advances in the genetic technology that is allowing researchers to examine host-pathogen interactions at a whole organism level.
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CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based studyTo look at the interplay between PMN and macrophages in disease progression in humans we asked whether polymorphisms at genes that regulate their infiltration..