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Associations of maternal prepregnancy body mass index and gestational weight gain with cardio-metabolicPrepregnancy body mass index (BMI) and early-pregnancy weight gain rate are associated with adverse adolescent cardio-metabolic profile.
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Effects of pregnancy and lactation prebiotics supplementation on infant allergic disease: A randomized controlled trialIngestion of prebiotics during pregnancy and lactation may have immunomodulatory benefits for the developing fetal and infant immune system and provide a potential dietary strategy to reduce the risk of allergic diseases. We sought to determine whether maternal supplementation with dietary prebiotics reduces the risk of allergic outcomes in infants with hereditary risk.
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Impact of assisted reproductive technologies on intrauterine growth and birth defects in singletonsThis paper presents data that infants born following assisted reproductive technologies (ART) compared with non-ART singletons display increases in low birth...
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Pragmatic Low-Dose Oral Immunotherapy for Preschool Children With Peanut Allergy: A Randomised Controlled TrialPeanut allergy is the most common childhood-onset, persistent food allergy. Peanut oral immunotherapy (OIT) is a potential treatment, but few studies prospectively examine the outcome of peanut OIT in young children using parent-measured doses compared to standard care (peanut avoidance).
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ART, birth defects and subfertility-what should prospective patients be told?Clinicians who counsel prospective ART patients about birth defect risk should provide information about the overall risk of having a child with a birth defect
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Maternal diet during breastfeeding: Could it influence food allergy risk in children?Human milk is rich in immuno-modulatory factors that have the potential to shape immune development and influence allergy risk in children. In this article, we describe how breast milk may contribute to making the infant less prone to developing allergies.
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Assisted Reproductive TechnologiesAssisted reproductive technologies (ART) cover a range of methods used to help couples with fertility problems achieve pregnancy, including in-vitro fertilisation (IVF).
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Asthma and allergies in a cohort of adolescents conceived with ARTResearch question: Are asthma and allergies more common in adolescents conceived with assisted reproductive technologies (ART) compared with adolescents conceived without?
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An exploration of cerebral palsy aetiology: assisted reproductive technology and congenital anomaliesThis project will explore in detail the role of two known risk factors for cerebral palsy: assisted reproductive technology and congenital anomalies.
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Remission of peanut allergy is associated with rewiring of allergen-driven T helper 2-related gene networksThe immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes.
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Intellectual disability in children conceived using assisted reproductive technologyThe risk of intellectual disability was increased in children born after assisted reproductive technology in Western Australia from 1994 to 2002
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Azithromycin inhibits mucin secretion, mucous metaplasia, airway inflammation, and airways hyperresponsiveness in mice exposed to house dust mite extractExcessive production, secretion, and retention of abnormal mucus is a pathological feature of many obstructive airways diseases including asthma. Azithromycin is an antibiotic that also possesses immunomodulatory and mucoregulatory activities, which may contribute to the clinical effectiveness of azithromycin in asthma.
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Linked data research: a valuable tool in the ART fieldThis letter to the editor endorses data linkage studies and cites their potential value over other types of epidemiological studies within the field of...
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Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut AllergyNo approved treatment for peanut allergy exists for children younger than 4 years of age, and the efficacy and safety of epicutaneous immunotherapy with a peanut patch in toddlers with peanut allergy are unknown.
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Assisted reproductive technology and major birth defects in Western australiaThe object of this work was to estimate the prevalence of major birth defects diagnosed by 6 years of age in all births and terminations of pregnancy for...
News & Events
New trial aims to reduce peanut allergy in childrenMothers eating a diet rich in peanuts while breastfeeding might be helping to reduce their baby’s risk of developing a peanut allergy – that’s the hypothesis of a new clinical trial that has been granted $2.29 million in funding by the National Health and Medical Research Council (NHMRC).
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Food Allergy Genetics and Epigenetics: A Review of Genome-Wide Association StudiesIn this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic research.
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Anaphylactic Reactions During Bee Venom Immunotherapy in the Paediatric PopulationA retrospective study will review episodes of anaphylaxis during bee venom immunotherapy in children, any modifications made to the dosing schedule, and the subsequent outcomes over a nine-year period in Western Australia.