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Research
Exploring the synthetic potential of a marine transaminase including discrimination at a remote stereocentreThe marine transaminase, P-ω-TA, can be employed for the transamination from 1-aminotetralins and 1-aminoindanes with differentiation of stereochemistry at both the site of reaction and at a remote stereocentre resulting in formation of ketone products with up to 93% ee. While 4-substituents are tolerated on the tetralin core, the presence of 3- or 8-substituents is not tolerated by the transaminase.
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Topical versus systemic antibiotics for chronic suppurative otitis mediaTo assess the relative effectiveness of topical versus systemic antibiotics for people with chronic suppurative otitis media
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Evaluation of safety and immunogenicity of a group a streptococcus vaccine candidate (mj8vax) in a randomized clinical trialIntramuscular administration of novel acetylated peptide-protein conjugate vaccine candidate MJ8VAX was demonstrated to be safe and immunogenic
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Trial refresh: A case for an adaptive platform trial for pulmonary exacerbations of cystic fibrosisThis review will discuss the necessary steps required for a Bayesian adaptive platform trial to optimize treatment of pulmonary exacerbations of cystic fibrosis
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Development of an opsonophagocytic killing assay for group a streptococcusThis Group A Streptococcus OPKA assay has the potential to provide a robust and reproducible platform to accelerate GAS vaccine development.
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Rheumatic heart disease in pregnancy: How can health services adapt to the needs of Indigenous women? A qualitative studyHealth systems did not meet the needs of pregnant Aboriginal women with rheumatic heart disease
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What is known about consumer nutrition environments in Australia? A scoping review of the literatureThis study aimed to summarize the attributes that have been examined in existing peer-reviewed studies of Australian consumer nutrition environments
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The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosisDe novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF25-75 in children with CF
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Aural toilet (ear cleaning) for chronic suppurative otitis mediaTo assess the effects of aural toilet procedures for people with chronic suppurative otitis media
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Addressing challenges in gaining informed consent for a research study investigating falls in people with intellectual disabilityThis study describes how an informed consent process was developed for people with intellectual disability and how it is working in a current study