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Clinical development strategy for a candidate group A streptococcal vaccineThis review outlines a clinical development strategy detailing the phases of development required for registration of a candidate Group A streptococci vaccin
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Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.We propose that this system provides a model for the differentiation and adaptation of monocytes entering the intestinal lamina propria.
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Vitamin D over the first decade and susceptibility to childhood allergy and asthmaWe aimed to research relationships between 25(OH)D levels from birth to 10 y/o and susceptibility to allergic sensitization, respiratory issues and asthma.
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The role of PKCzeta in cord blood T-cell maturation towards Th1 cytokine profile and its epigenetic regulation by fish oilHere, we present evidence that there are two major control points to explain the immunodeficiency in CB T-cells, leading to a decreased IFNy synthesis.
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Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adultsType 2 inflammation is present in patients during virus-induced asthma exacerbations, to the same degree as non-viral exacerbations
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Pulmonary delivery of virosome-bound antigen enhances antigen-specific CD4+ T cell proliferation compared to liposome-bound or soluble antigenPulmonary administration of biomimetic nanoparticles loaded with antigen may represent an effective strategy to directly modulate adaptive immune responses
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Induced sputum to detect lung pathogens in young children with cystic fibrosiswe aimed to determine the sensitivity and specificity of induced sputum with and without airway clearance techniques to detect lower airway pathogens in kids.
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Protective benefit of predominant breastfeeding against otitis media may be limited to early childhood: results from a prospective birth cohort studyOur findings are in line with a number of epidemiological studies which show a positive association between breastfeeding and OM in early childhood
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Rheumatic heart disease across the Western Pacific: not just a Pacific Island problemWe aimed to review RHD burden in Western Pacific Region outside Oceania to identify countries with high RHD burden
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Self-harm: Prevalence estimates from the second Australian Child and Adolescent Survey of Mental Health and WellbeingThe demonstrated higher risks in young people for continued harm or possible death support the need for ongoing initiatives to reduce self-harm