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Research

Apgar score and risk of autism

This study suggests that low Apgar score is associated with higher risk of autism spectrum disorder, and in particular autistic disorder

Research

Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress

Here, we demonstrate that group A Streptococcus (GAS) utilises Mn(II) import via MtsABC during conditions of hydrogen peroxide stress

Research

Features of the metabolic syndrome in late adolescence are associated with impaired testicular function at 20 years of age

Adolescents with features of metabolic disorder or insulin resistance show impaired testicular function and altered hormone levels

Research

The politics of picking: Selective vaccinators and population-level policy

Public health systems face tensions between individuals and the collective. Parents who selectively vaccinate demonstrate this tension

Research

Low positive predictive value of International Classification of Diseases, 10th Revision codes in relation to rheumatic heart disease: a challenge for global surveillance

We outline a series of research initiatives to improve identification of RHD in administrative data thereby contributing to monitoring the RHD burden globally

Research

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

These findings implicate the activation of STAT3 as one pathway that may mediate resistance to IGF-II-targeted therapy in HCC

Research

Increased Use of Adrenaline in the Management of Childhood Anaphylaxis Over the Last Decade

There was a significant improvement in the management of anaphylaxis after the introduction of intensified physician training programs

Research

Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models

This JAK3A572V knockin model is a relevant new tool for testing the efficacy of JAK inhibitors in JAK3-related hematopoietic malignancies

Research

Respiratory function in healthy Emirati children using forced oscillations

Forced oscillation technique measurements were feasible in Emirati school-children. New forced oscillation technique reference equation in Emirati children were derived.

Research

Using linked data to investigate developmental vulnerabilities in children of convicted parents

Although children of convicted parents experience a higher incidence of sociodemographic risk, their parents' criminal activity constitutes an independent risk factor for their development